Beautiful Bill and Andy, newly released from a mandatory stint at a mental hospital, are best friends. Their inability to conform to society at large results in some frightening "acting out." After their therapist fails at advising them on how to reintegrate back into society, Bill has an epiphany. What they need, he decides, is romantic love. After a disastrous attempt at wooing "normal women," they realize they need to meet women who are "genuinely crazy" like themselves. So they post up outside of a mental health facility for women. This is how they meet Bonnie. And though Bonnie and Andy soon fall into a relationship, Bill finds himself playing the part of the third wheel. However, when Bonnie reveals she's pregnant, Bill sees a chance to get back in her good graces. His ensuing plan to rob a bank and give the proceeds to Bonnie kicks off a years-long series of madcap adventures that challenge not only Bill and Andy's friendship, but their already tenuous grasp on sanity.